Chemical Name: 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Biological ActivityTeriflunomide is an inhibitor of dihydroorotate dehydrogenase (Kd = 12 nM; Ki = 179 nM). Inhibits proliferation of mitogen- or cytokine-stimulated lymphoid cells in vitro by inhibiting cell cycle progression from G1 to S. Imunosuppressive agent. Active metabolite of leflunomide (Cat. No. 2228).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic stimulation-induced motor-evoked potentials in the dark agouti rat model of experimental autoimmune encephalomyelitis.
Iglesias-Bregna et al.
Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound.
Williamson et al.
The immunosuppressive metabolite of leflun. is a potent inhibitor of human dihydroorotate dehydrogenase.
Davis et al.
Citation for Teriflunomide
The citations listed below are publications that use Tocris products. Selected citations for Teriflunomide include:
1 Citation: Showing 1 - 1
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
Authors: Styr Et al.
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