Biological ActivityBlocker of Kir1.1 channels; displays >250-fold selectivity for Kir1.1 (Kd values are 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4 respectively). Derivative of tertiapin-Q (Cat. No. 1316).
(Modifications: Disulfide bridge between 3 - 14, 5 - 18, Lys-21 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels.
Ramu et al.
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