A high affinity blocker for inward-rectifier K+
channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir
1.1) and GIRK1/4 (Kir
3.1/3.4) channels with high affinity (Ki
values are 1.3 and 13.3 nM respectively) and is selective over Kir
2.1 channels. Derivative tertiapin LQ
(Cat. No. 4339) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license granted by the University of Pennsylvania
Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q.
Jin et al.
Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels.
Jin and Lu
The citations listed below are publications that use Tocris products. Selected citations for Tertiapin-Q include:
Showing Results 1 - 5 of 5