Catalog Number: 1316
Biological Activity
A high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and is selective over Kir2.1 channels. Derivative tertiapin LQ (Cat. No. 4339) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Disulfide bridge between 3 - 14, 5 - 18, Lys-21 = C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license granted by the University of Pennsylvania
Background References
  1. Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q.
    Jin et al.
    Biochemistry, 1999;38:14294
  2. Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels.
    Jin and Lu
    Biochemistry, 1999;38:14286
Tocris Peptides
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Tertiapin LQ

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