TFRGAP-NH2
Tocris Bioscience | Catalog # 7742
PAR3 peptide agonist
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Key Product Details
Description
PAR3 peptide agonist
Product Description
TFRGAP-NH2 is a protease-activated receptor 3 (PAR3) peptide agonist. In vitro, it increases the expression of heme oxygenase (HO)-1 in osteoarthritis synovial fibroblasts (OASFs).
Product Specifications for TFRGAP-NH2
Molecular Weight
646.75
Formula
C29H46N10O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
1872435-09-0
PubChem ID
162678814
InChI Key
SZHZUHWALRYMHX-WZZXNIEWSA-N
SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C)C(N2[C@@H](CCC2)C(N)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Background References
References are publications that support the biological activity of the product.
- Liu Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways. Arthritis Res.Ther. 2012 PMID: 22541814
- Lin c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells. J.Immunol. 2006 PMID: 16920985
- Mogami Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J.Biol.Chem. 2014 PMID: 24652285
- Iyer PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clotting. Front Physiol. 2021 PMID: 33776786
- Yu Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role. Cell Death Discov. 2021 PMID: 34753916
- Subramaniam A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C). Blood Adv. 2021 PMID: 34242391
Product Documents for TFRGAP-NH2
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for TFRGAP-NH2
For research use only
Citations for TFRGAP-NH2
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