TG 003

Key Product Details

Product Description

TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases (IC₅₀ values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC₅₀ values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.

Product Specifications for TG 003

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TG 003

The following data is based on the product molecular weight 249.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.01 mL	20.05 mL	40.11 mL
5 mM	0.80 mL	4.01 mL	8.02 mL
10 mM	0.40 mL	2.01 mL	4.01 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Foucourt Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II. Molecules 2014 PMID: 25264830
• Muraki Manipulation of alternative splicing by a newly developed inhibitor of Clks. J.Biol.Chem. 2004 PMID: 15010457

Product Documents for TG 003