Aquaporin 4 (AQP4) channel blocker (IC50
= 3.1 μ
M). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
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Inhibition of aquaporin-4 significantly increases regional cerebral blood flow.
Igarashi et al.
Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema.
Igarashi and Huber
Identification of aquaporin 4 inhibitors using in vitro and in silico methods.
Huber et al.