Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Biological ActivityTGN 020 is an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of aquaporin 4 inhibitors using in vitro and in silico methods.
Huber et al.
Inhibition of aquaporin-4 significantly increases regional cerebral blood flow.
Igarashi et al.
Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema.
Igarashi and Huber
Citations for TGN 020
The citations listed below are publications that use Tocris products. Selected citations for TGN 020 include:
2 Citations: Showing 1 - 2
Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.
Authors: Harrison Et al.
Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1.
Authors: Wang Et al.
J Biol Chem 2017;292:8291
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