Catalog Number: 5425
Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Biological Activity
Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO and to 10 mM in 1eq. HCl with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of aquaporin-4 significantly increases regional cerebral blood flow.
    Igarashi et al.
    Neuroreport, 2013;24:324
  2. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema.
    Igarashi and Huber
    Neurol.Sci., 2011;32:113
  3. Identification of aquaporin 4 inhibitors using in vitro and in silico methods.
    Huber et al.
    Bioorg.Med.Chem., 2009;17:411
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