Chemical Name: N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Biological ActivityThalidomide 4'-oxyacetamide-alkylC4-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
This product has been recently renamed. The previous name for this product was Thalidomide - linker 3
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage GuidelinesThis product is provided for use in onward chemistry. Suitable solvents can be used.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Waste disposal-An attractive strategy for cancer therapy.
Salami et al.
Drug development. Phthalimide conjugation as a strategy for in vivo target protein degradation.
Winter et al.
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