Chemical Name: 2-((1E,3E)-5-((E)-1-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium-5-sulfonate
Biological ActivityThalidomide-Cyanine 5 is a fluorescent probe for cereblon E3 ligases. Binds with high affinity to DDB1-CRBN. Suitable for use in TR-FRET.
Optical Data for Thalidomide-Cyanine 5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Fischer ES, Bohm K, Lydeard JR et al.
Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase.
Petzold et al.
Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Cavadini et al.
Demonstrating in-cell target engagement using a pirin protein degradation probe (CCT367766).
Chessum et al.
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