Thioflavin T

Catalog # Availability Size / Price Qty
7122/500

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Thioflavin T | CAS No. 2390-54-7 | Fluorescent Amyloid B Probes
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Description: Fluorescent amyloid stain, binds to the stacked β sheets of amyloid fibrils

Chemical Name: 2-[4-(Dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride

Purity: ≥95%

Product Details
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Biological Activity

Thioflavin T is a cell-permeable fluorescent amyloid stain. This cationic benzothiazole dye increases in fluorescence upon binding to the stacked β sheets of amyloid fibrils. Thioflavin T is used to confirm formation of β sheet structure from mutant huntingtin exon-1 aggregates (Ex1Q48) in vitro. Thioflavin T is also used to monitor the kinetics of in vitro polyglutamine amyloid formation of tNhtt-42Q aggregates in a Huntington's disease cell model. Insoluble senile plaques of Aβ in brain tissues are commonly stained with Thioflavin T. Excitation/emission maxima = 440/485 nm.

This product is supplied with a high degree of hydration and some residual inorganic salts, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Optical Data for Thioflavin T

Emission Color Blue
λabs 440 nm
λem 485 nm
Extinction Coefficient (ε) 31600 M-1cm-1
Quantum Yield (φ) 0.43
Cell Permeable Yes
Application amyloid stain

Technical Data

M.Wt:
318.86
Formula:
C17H19ClN2S
Solubility:
Soluble to 5 mM in DMSO and to 10 mM in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2390-54-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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