Chemical Name: N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
Biological ActivityThiolutin is an antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.
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RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus.
O'Neill et al.
Antimicrob.Agents Chemother., 2000;44:3163
Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae.
Jimenez et al.
Antimicrob.Agents Chemother., 1973;3:729
Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis.
Minamiguchi et al.
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Used in study to figure out if Thiolutin suppresses tumor cell-induced angiogenesis.