Catalog Number: 1567
Chemical Name: N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
Biological Activity
Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mg/ml in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae.
    Jimenez et al.
    Antimicrob.Agents Chemother., 1973;3:729
  2. Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis.
    Minamiguchi et al.
    Int.J.Cancer, 2001;93:307
  3. RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus.
    O'Neill et al.
    Antimicrob.Agents Chemother., 2000;44:3163
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information