Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50
= 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae.
Jimenez et al.
Antimicrob.Agents Chemother., 1973;3:729
Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis.
Minamiguchi et al.
RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus.
O'Neill et al.
Antimicrob.Agents Chemother., 2000;44:3163