Dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1
cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells.
Kang et al.
Apoptosis., 2012;Mar 30:Epub ahead of print
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells.
Sachlos et al.
Cell., 2012;May 23.:Epub ahead of print
The citations listed below are publications that use Tocris products. Selected citations for Thioridazine hydrochloride include:
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