Chemical Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Biological Activity Dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.
Soluble to 75 mM in water and to 100 mM in DMSO
Desiccate at RT
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Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
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