Thioridazine hydrochloride

Key Product Details

Product Description

Thioridazine hydrochloride is a dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G₁ cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.

Product Specifications for Thioridazine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Thioridazine hydrochloride

The following data is based on the product molecular weight 407.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.28 mL	24.57 mL
5 mM	0.49 mL	2.46 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Kang Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 PMID: 22460505
• Sachlos Identification of drugs including a DA receptor antagonist that selectively target cancer stem cells. Cell. 2012 PMID: 22632761

Product Documents for Thioridazine hydrochloride