Chemical Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Biological ActivityThioridazine hydrochloride is a dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of drugs including a DA receptor antagonist that selectively target cancer stem cells.
Sachlos et al.
Cell., 2012;May 23.:Epub ahead of print
Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells.
Kang et al.
Apoptosis., 2012;Mar 30:Epub ahead of print
Citation for Thioridazine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Thioridazine hydrochloride include:
1 Citation: Showing 1 - 1
Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists.
Authors: Chigaev Et al.
J Biol Chem 2011;286:5455
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