Catalog Number: 3267
Biological Activity
Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
Technical Data
  • M.Wt:
    1664.89
  • Formula:
    C72H85N19O18S5
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >90%
  • Storage:
    Store at -20°C
  • CAS No:
    1393-48-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Thiostrepton inhibition of tRNA delivery to the ribosome.
    Ruben et al.
    RNA, 2007;13:2091
  2. Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression.
    Kwok et al.
    Mol.Cancer Ther., 2008;7:2022
  3. Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.
    Rodnina et al.
    Proc.Natl.Acad.Sci.USA, 1999;96:9586
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Thiostrepton include:

1 Citations: Showing 1 - 1

  1. Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.
    Authors: Uddin Et al.
    Am J Pathol 2011;178:537

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