Thiostrepton

Catalog # Availability Size / Price Qty
3267/50
Thiostrepton | CAS No. 1393-48-2 | Antibiotics
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Description: Antibiotic, inhibits protein synthesis

Purity: ≥90%

Product Details
Citations (3)
Reviews (1)

Biological Activity

Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

Technical Data

M.Wt:
1664.89
Formula:
C72H85N19O18S5
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥90%
Storage:
Store at -20°C
CAS No:
1393-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Thiostrepton inhibition of tRNA delivery to the ribosome.
    Ruben et al.
    RNA, 2007;13:2091
  2. Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression.
    Kwok et al.
    Mol.Cancer Ther., 2008;7:2022
  3. Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.
    Rodnina et al.
    Proc.Natl.Acad.Sci.USA, 1999;96:9586

Product Datasheets

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Citations for Thiostrepton

The citations listed below are publications that use Tocris products. Selected citations for Thiostrepton include:

3 Citations: Showing 1 - 3

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Thiostrepton was used to treat acquired cisplatin resistance
By Anonymous on 02/27/2019
Species: Human

Thiostrepton was used to treat acquired cisplatin resistance in breast cancer cells under in in vitro conditions.


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