Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
Soluble to 10 mM in DMSO
Store at -20°C
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Thiostrepton inhibition of tRNA delivery to the ribosome.
Ruben et al.
Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression.
Kwok et al.
Mol.Cancer Ther., 2008;7:2022
Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.
Rodnina et al.
The citations listed below are publications that use Tocris products. Selected citations for Thiostrepton include:
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