Biological ActivityAntibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Thiostrepton inhibition of tRNA delivery to the ribosome.
Ruben et al.
Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression.
Kwok et al.
Mol.Cancer Ther., 2008;7:2022
Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.
Rodnina et al.
Citations for Thiostrepton
The citations listed below are publications that use Tocris products. Selected citations for Thiostrepton include:
3 Citations: Showing 1 - 3
FoxM1 Induced PTX Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter.
Authors: Huang Et al.
Mol Ther Oncolytics 2019;14:196
Inhibition of FOXM1 by thiostrepton sensitizes medulloblastoma to the effects of chemotherapy.
Authors: Lin Et al.
Oncol Rep 2013;30:1739
Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.
Authors: Uddin Et al.
Am J Pathol 2011;178:537
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Thiostrepton was used to treat acquired cisplatin resistance in breast cancer cells under in in vitro conditions.