Biological ActivityThiostrepton is an antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
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Thiostrepton inhibition of tRNA delivery to the ribosome.
Ruben et al.
Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression.
Kwok et al.
Mol.Cancer Ther., 2008;7:2022
Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.
Rodnina et al.
Citations for Thiostrepton
The citations listed below are publications that use Tocris products. Selected citations for Thiostrepton include:
3 Citations: Showing 1 - 3
FoxM1 Induced PTX Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter.
Authors: Huang Et al.
Mol Ther Oncolytics 2019;14:196
Inhibition of FOXM1 by thiostrepton sensitizes medulloblastoma to the effects of chemotherapy.
Authors: Lin Et al.
Oncol Rep 2013;30:1739
Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.
Authors: Uddin Et al.
Am J Pathol 2011;178:537
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Thiostrepton was used to treat acquired cisplatin resistance in breast cancer cells under in in vitro conditions.