Potent and selective melanocortin 4 (MC4
) receptor agonist (IC50
values are 1.2, 761 and 2067 nM for human MC4
receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.
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All Tocris products are intended for laboratory research use only.
Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula.
Martin et al.
Design and pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-methyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective melanocorti
Sebhat et al.
New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ".
Mutulis et al.
The citations listed below are publications that use Tocris products. Selected citations for THIQ include:
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