THIQ

Catalog # Availability Size / Price Qty
3032/1
THIQ | CAS No. 312637-48-2 | Melanocortin Receptor Agonists
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Description: Potent and selective MC4 receptor agonist

Chemical Name: N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide

Purity: ≥95%

Product Details
Citations (3)
Supplemental Products
Reviews (1)

Biological Activity

Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 1.2, 761 and 2067 nM for human MC4, MC3 and MC1 receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.

Technical Data

M.Wt:
589.17
Formula:
C33H41ClN6O2
Solubility:
Soluble to 10 mM in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
312637-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for THIQ

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3 Citations: Showing 1 - 3

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THIQ treatment increase social interactions
By Anonymous on 01/11/2019
Species: Mouse

Recently, we demonstrated that the deletion of the NFKB1 gene, which encodes the p50 NF-kappa B subunit, causes impairment in social behaviours, with reductions in social interactions in mice. In this work, we tested the acute effects of THIQ, a selective melanocortin 4 receptor (MC4R) agonist. THIQ treatment increased social interactions both in wild type and p50-/- mice. In particular, after treatment with THIQ, p50-/- mice showed a prosocial behaviour analogous to that of basal WT mice.


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