Agonist at the thrombin receptor; causes platelet aggregation (EC50
= 4 μ
M) and secretion.
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'Thrombin' receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides.
Huang et al.
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
Vu et al.
Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides.
Vassallo et al.
The citations listed below are publications that use Tocris products. Selected citations for Thrombin Receptor Agonist Peptide include:
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