Catalog Number: 1185
Alternate Names: TRAP
Biological Activity
Agonist at the thrombin receptor; causes platelet aggregation (EC50 = 4 μM) and secretion.
Technical Data
  • M.Wt:
    1739
  • Formula:
    C81H118N20O23
  • Sequence:
    SFLLRNPNDKYEPF
  • Solubility:
    Soluble to 0.90 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    137339-65-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 'Thrombin' receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides.
    Huang et al.
    J.Biol.Chem., 1991;266:18435
  2. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
    Vu et al.
    Cell, 1991;64:1057
  3. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides.
    Vassallo et al.
    J.Biol.Chem., 1992;267:6081
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Thrombin Receptor Agonist Peptide include:

2 Citations: Showing 1 - 2
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  1. A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
    Authors: White Et al.
    J Endocrinol 2015;194:142
  2. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
    Authors: Tripathi Et al.
    Invest Ophthalmol Vis Sci 2014;55:3912

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