Thyroglobulin Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-90200

Novus Biologicals
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Thyroglobulin Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: KMCSADYADLLQTFQVFILDELTARGFCQIQVKTFGTLVSIPVCNNSSVQVGCLTRERLGVNVTWKSRLEDIPVASLPDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGCSEGFYQVLTSEASQDGLGCVKCPEGS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Thyroglobulin Antibody - BSA Free

Thyroglobulin Antibody - BSA Free Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Analysis in human thyroid gland and liver tissues using NBP1-90200 antibody. Corresponding TG RNA-seq data are presented for the same tissues.
Thyroglobulin Antibody - BSA Free Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Staining of human thyroid gland shows strong positivity in plasma.
Thyroglobulin Antibody - BSA Free Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Staining of human liver shows no positivity in hepatocytes as expected.
Thyroglobulin Antibody - BSA Free Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Staining of human rectum shows no positivity in glandular cells as expected.
Thyroglobulin Antibody - BSA Free Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Immunohistochemistry: Thyroglobulin Antibody - BSA Free [NBP1-90200]

Staining of human lymph node shows no positivity in non-germinal center cells as expected.

Applications for Thyroglobulin Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Thyroglobulin

Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid. Thyroglobulin is the glycoprotein precursor to the thyroid hormones. Its synthesis and metabolism have seemingly wasteful features. It has a molecular weight of 660,000, with 2 identical subunits of MW 300,000 and 10% sugars; yet its complete hydrolysis yields only 2 to 4 molecules of the iodothyroxines T4 and T3. Baas et al. (1986) showed that the TG gene encodes an 8.7-kb mRNA, covers at least 300 kb of genomic DNA and contains at least 37 exons separated by introns as large as 64 kb. A striking structural difference between the 5-prime and 3-prime parts of the gene suggested that it is composed of 2 evolutionarily different regions. The first 30 kb of DNA encodes 3 kb of the mRNA yielding an exon:intron ratio of 1:10, whereas the remaining 270 kb encodes 5.7 kb of the mRNA with a ratio of 1.47.

Alternate Names

AITD3, cog, TDH3, Tg, TGN

Gene Symbol

TG

Additional Thyroglobulin Products

Product Documents for Thyroglobulin Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Thyroglobulin Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cancer Biomarkers

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Protocols

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