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Tianeptine sodium salt

Catalog #: 1972
2 Citations Datasheet / COA / SDS

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1972 has been discontinued.
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Tianeptine sodium salt | CAS No. 30123-17-2 | 5-HT Transporter Compounds
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Description: Selective facilitator of 5-HT uptake; antidepressant

Chemical Name: 7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid sodium salt

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.

Technical Data

M.Wt:
458.93
Formula:
C21H24ClN2NaO4S
Solubility:
Soluble to 100 mM in water and to 10 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
30123-17-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells.
    Makani, Vishruti, Hall, James, Qamar, Khola, Jain, Priyanka, Jang, Yonggil, Hensley, Kenneth, Park, Joshua J
    Mol Cell Endocrinol, 2013;381(1):175-87.
  2. Neurochemical profile of tianeptine, a new antidepressant drug.
    Kato and Weitsch
    Clin.Neuropharmacol., 1988;11:S43
  3. Analgesic effect of tianeptine in mice.
    Uzbay et al.
    Life Sci., 1999;64:1313
  4. Neuroprotective properties of tianeptine: interactions with cytokines.
    Plaisant et al.
    Neuropharmacology, 2003;44:801
  5. Tianeptine, a selective enhancer of serotonin uptake in rat brain.
    Mennini et al.
    Naunyn-Schmied.Arch.Pharmacol., 1987;336:478

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Citations for Tianeptine sodium salt

The citations listed below are publications that use Tocris products. Selected citations for Tianeptine sodium salt include:

2 Citations: Showing 1 - 2

  1. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
    Authors: Czysz Et al.
    Nature  2015;40:766
  2. Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells.
    Authors: Makani Et al.
    Mol Cell Endocrinol  2013;381:175

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