Catalog Number: 1972
Chemical Name: 7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid sodium salt
Biological Activity
Selective facilitator of 5-HT uptake in vitro and in vivo. Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.
Technical Data
  • M.Wt:
    458.93
  • Formula:
    C21H24ClN2NaO4S
  • Solubility:
    Soluble to 100 mM in water and to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    30123-17-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neurochemical profile of tianeptine, a new antidepressant drug.
    Kato and Weitsch
    Clin.Neuropharmacol., 1988;11:S43
  2. Analgesic effect of tianeptine in mice.
    Uzbay et al.
    Life Sci., 1999;64:1313
  3. Neuroprotective properties of tianeptine: interactions with cytokines.
    Plaisant et al.
    Neuropharmacology, 2003;44:801
  4. Tianeptine, a selective enhancer of serotonin uptake in rat brain.
    Mennini et al.
    Naunyn-Schmied.Arch.Pharmacol., 1987;336:478
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tianeptine sodium salt include:

2 Citations: Showing 1 - 2
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  1. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
    Authors: Czysz Et al.
    Nature 2015;40:766
  2. Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells.
    Authors: Makani Et al.
    Mol Cell Endocrinol 2013;381:175

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