Tianeptine sodium salt
Chemical Name: 7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid sodium salt
Biological ActivitySelective facilitator of 5-HT uptake in vitro and in vivo. Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Neurochemical profile of tianeptine, a new antidepressant drug.
Kato and Weitsch
Analgesic effect of tianeptine in mice.
Uzbay et al.
Life Sci., 1999;64:1313
Neuroprotective properties of tianeptine: interactions with cytokines.
Plaisant et al.
Tianeptine, a selective enhancer of serotonin uptake in rat brain.
Mennini et al.
Citations for Tianeptine sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Tianeptine sodium salt include:
2 Citations: Showing 1 - 2
Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells.
Authors: Makani Et al.
Mol Cell Endocrinol 2013;381:175
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