Tiotidine (CAS 69014-14-8): R&D Systems
Catalog Number: 0826
Alternate Names: ICI 125,211
Biological Activity
Potent histamine H2-receptor antagonist with negligible activity against H1- and H3- receptors.
Technical Data
  • M.Wt:
    312.41
  • Formula:
    C10H16N8S2
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    69014-14-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. ICI 125,211: A new gastric antisecretory agent acting on histamine H2- receptors.
    Yellin et al.
    Life Sci., 1979;25:2001
  2. The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H2- receptor antagonist.
    Trzeciakowski and Levi
    J.Pharmacol.Exp.Ther., 1980;214:629
  3. Distribution, properties, and functional characteristics of three classes of histamine receptor.
    Hill et al.
    Pharmacol.Rev., 1990;42:45
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tiotidine include:

2 Citations: Showing 1 - 2
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  1. Physiological implications of biased signaling at histamine H2 receptors.
    Authors: Alonso Et al.
    Exp Ther Med 2015;6:45
  2. Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
    Authors: Holden Et al.
    Front Pharmacol 2007;152:891

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