Tiotropium bromide

Key Product Details

Product Description

Tiotropium bromide is a potent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro (IC₅₀ = 0.17 nM). Induces smooth muscle relaxation and bronchodilation.

Product Specifications for Tiotropium bromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tiotropium bromide

The following data is based on the product molecular weight 472.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.58 mL	21.17 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Smit Bronchoprotection by olodaterol is synergistically enhanced by tiotr. in a guinea pig model of allergic asthma. J.Pharmacol.Exp.Ther. 2014 PMID: 24307202
• Ogoda Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrr. J.Pharm.Sci. 2011 PMID: 21358117
• Takahashi Effect of Ba 679 BR, a novel long-acting anticholin. agent, on cholinergic neurotransmission in guinea pig and human airways. Am.J.Respir.Crit.Care Med. 1994 PMID: 7952627

Product Documents for Tiotropium bromide