Tiplaxtinin

Catalog # Availability Size / Price Qty
5565/10
5565/50
Cat.No. 5565 - Tiplaxtinin | C24H16F3NO4 | CAS No. 393105-53-8
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Description: Plasminogen activator inhibitor-1 (PAI-1) inhibitor
Alternative Names: PAI 039, tiplasinin

Chemical Name: α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid

Product Details
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Biological Activity

Plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 2.7 μM). Induces vascular smooth muscle cell apoptosis in vitro and reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute arterial thrombosis. Orally available.

Technical Data

Formula:
C24H16F3NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
393105-53-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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