TL 13-110

Tocris Bioscience | Catalog # 6746

Negative control for TL 13-112 (Cat. No. 6745)
Tocris Bioscience

Key Product Details

Description

Negative control for TL 13-112 (Cat. No. 6745)
View all Active Degrader Negative Controls »

Product Description

TL 13-110 is a negative control for TL 13-112 (Cat. No. 6745). Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for TL 13-110

Molecular Weight

988.59

Formula

C49H62ClN9O9S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide

CAS Number

2229037-09-4

SMILES

CC(C)OC1=CC(C2CCN(CCOCCOCCNC(CNC3=CC=CC4=C3C(N(C5CCCNC5=O)C4=O)=O)=O)CC2)=C(C)C=C1NC6=NC=C(Cl)C(NC7=CC=CC=C7S(=O)(C(C)C)=O)=N6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.43 50

Preparing Stock Solutions for TL 13-110

The following data is based on the product molecular weight 988.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.02 mL 10.12 mL 20.23 mL
2.5 mM 0.40 mL 2.02 mL 4.05 mL
5 mM 0.20 mL 1.01 mL 2.02 mL
25 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for TL 13-110

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TL 13-110

For research use only

Customer Reviews for TL 13-110

There are currently no reviews for this product. Be the first to review TL 13-110 and earn rewards!

Have you used TL 13-110?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card