TMI 1

Tocris Bioscience | Catalog # 5960

Adam 17 (TACE) and MMP inhibitor; orally bioavailable
Tocris Bioscience

Key Product Details

Description

Adam 17 (TACE) and MMP inhibitor; orally bioavailable
View all Synthetic Metalloprotease Inhibitors »

Product Description

TMI 1 is an ADAM17 (TACE) and MMP inhibitor (IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF-α production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro. Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Product Specifications for TMI 1

Molecular Weight

398.49

Formula

C17H22N2O5S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide

CAS Number

287403-39-8

PubChem ID

5288615

InChI Key

CVZIHNYAZLXRRS-HNNXBMFYSA-N

SMILES

CC1(C)SCCN(S(C2=CC=C(OCC#CC)C=C2)(=O)=O)[C@H]1C(NO)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.85 100
Ethanol 7.97 20

Preparing Stock Solutions for TMI 1

The following data is based on the product molecular weight 398.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.09 mL
5 mM 0.50 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for TMI 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TMI 1

For research use only

Customer Reviews for TMI 1 (1)

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  • Selective effect of TMI-1 was observed for caspase-dependent apoptosis
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 10/12/2019
    Selective effect of TMI-1 was observed for caspase-dependent apoptosis. TMI-1 was observed for efficient in 34/40 tumor cell lines of various origins.
    TMI 1 5960

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