Adam 17 (TACE) and MMP inhibitor (IC50
values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF-α
production in an acute LPS-mouse model. Reduces severity score in an in vivo
model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro
. Induces tumor apoptosis in a breast cancer in vivo
model. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc
Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer
Mezil et al.
PLoS One, 2012;7:e43409
Heterocyclic inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-α-converting enzyme/matrix meta
Zhang et al.