Chemical Name: 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)
Biological ActivityTMPyP4 tosylate is a cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Effect of telomere and telomerase interactive agents on human tumor and normal cell lines.
Rha et al.
Clin.Cancer Res., 2000;6:987
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Shammas et al.
Mol.Cancer Ther., 2003;2:825
Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA.
Wheelhouse et al.
Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.
Shi et al.
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