TMPyP4 tosylate

Key Product Details

Product Description

TMPyP4 tosylate is a cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.

Product Specifications for TMPyP4 tosylate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TMPyP4 tosylate

The following data is based on the product molecular weight 1363.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.47 mL	7.33 mL	14.67 mL
2.5 mM	0.29 mL	1.47 mL	2.93 mL
5 mM	0.15 mL	0.73 mL	1.47 mL
25 mM	0.03 mL	0.15 mL	0.29 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Shi Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem.
• Shammas Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2003 PMID: 14555701
• Wheelhouse Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc.
• Rha Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 2000 PMID: 10741725

Product Documents for TMPyP4 tosylate