Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μ
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All Tocris products are intended for laboratory research use only.
Effect of telomere and telomerase interactive agents on human tumor and normal cell lines.
Rha et al.
Clin.Cancer Res., 2000;6:987
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Shammas et al.
Mol.Cancer Ther., 2003;2:825
Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA.
Wheelhouse et al.