Catalog Number: 4253
Chemical Name: 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)
Biological Activity
Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.
Technical Data
  • M.Wt:
    1363.6
  • Formula:
    C72H66N8O12S4
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >95%
  • Storage:
    Store at +4°C
  • CAS No:
    36951-72-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effect of telomere and telomerase interactive agents on human tumor and normal cell lines.
    Rha et al.
    Clin.Cancer Res., 2000;6:987
  2. Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
    Shammas et al.
    Mol.Cancer Ther., 2003;2:825
  3. Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA.
    Wheelhouse et al.
    J.Am.Chem.Soc., 1998;120:3261

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