Tocriscreen 2.0 Max
Biological Activity
Tocriscreen 2.0 Max is a library of 1280 biologically active compounds from the Tocris catalog. Covers a wide range of pharmacological targets and research areas. Compounds are supplied pre-dissolved in 250 μL 10 mM DMSO solutions. A smaller volume is available as Tocriscreen 2.0 Mini (Cat. No. 7151) and Tocriscreen 2.0 Micro (Cat. No. 7152).This library replaces the Tocriscreen Plus (Cat. No. 5840).
For more information on the Tocriscreen 2.0 Compound Libraries, please download our informative flyer.
If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.
Key Format and Product Details
- 96-well racks with Matrix storage tubes & SepraSeal caps
- Compounds arranged 80 per rack with 16 racks per library
- Pre-dissolved in DMSO
- Many compounds are exclusive to Tocris
- Unique library with low overlap
- Full chemical and biological data available
- Exceptional purity
The Tocriscreen 2.0 Compound Library contains bioactive compounds covering a diverse range of molecular targets; 7-TM receptors (GPCRs; 27%), non-kinase enzymes (21%), kinases including enzyme-linked receptors (20%), ion channels (13%), cell biology targets (9%), nuclear receptors (6%), and transporters and other pharmacological targets (5%).
Request Compound List
A list of the compounds available in the Tocriscreen 2.0 Max can be requested in Excel or SD format via our Tocriscreen & Custom Library Inquiries form.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.
Li et al.
Cell Research, 2011;21:196 -
Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.
Hattori et al.
Proc.Natl.Acad.Sci.USA, 2010;107:3546 -
Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons.
Li et al.
Cell Stem Cell, 2015;17:195 -
Small molecules enhance CRISPR genome editing in pluripotent stem cells.
Yu et al.
Cell Stem Cell, 2015;16:142 -
Cell-based potassium ion channel screening using the FluxORTM assay.
Beacham et al.
J.Biomol.Screen., 2010;15:44
Product Datasheets
Reconstitution Calculator
Citations for Tocriscreen 2.0 Max
The citations listed below are publications that use Tocris products. Selected citations for Tocriscreen 2.0 Max include:
17 Citations: Showing 1 - 10
-
Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform.
Authors: Gruber Et al.
Hum.Reprod. 2022;:deac007
-
HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E-mutant high-grade glioma.
Authors: Sasame Et al.
Clin.Cancer Res. 2022;28:2425
-
Screening of chemical libraries using xenopus embryos and tadpoles for phenotypic drug discovery.
Authors: Gull Et al.
Cold Spring Harb.Protoc. 2022;
-
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG.
Authors: Ehteda Et al.
Cell Rep 2021;35:108994
-
A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells
Authors: Chen Et al.
Nat.Methods 2021;18:528
-
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma.
Authors: Endersby Et al.
Sci Transl Med 2021;13:eaba7401
-
Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody.
Authors: Tanaka Et al.
Sci Rep 2021;11:1712
-
Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists.
Authors: Tian Et al.
J Med Chem 2020;63:6164
-
High-throughput screening identified mitoxantrone to induce death of hepatocellular carcinoma cells with autophagy involvement.
Authors: Xie Et al.
Biochem.Biophys.Res.Commun. 2020;521:232
-
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
Authors: Telpoukhovskaia Et al.
Science Reports 2020;10:13688
-
Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.
Authors: Lake Et al.
BioRXiv 2020;
-
Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant.
Authors: Diamantopoulou Et al.
Elife 2019;8:e44889
-
A library screening strategy combining the concepts of MS binding assays and affinity selection mass spectrometry.
Authors: Gabriel Et al.
Front Chem 2019;7:665
-
Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays.
Authors: Danthi Et al.
SLAS Discov 2019;24:111
-
Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
Authors: Yang Et al.
Cell 2017;169:243
-
Drug Repurposing Screening Identifies Novel Compounds That Effectively Inhibit Toxoplasma gondii Growth.
Authors: Dittmar Et al.
mSphere 2016;1:e00042
-
Tubulin is a molecular target of the Wnt-activating chemical probe.
Authors: Fukuda Et al.
BMC Biochemistry 2016;17:9
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Tocriscreen 2.0 Max
There are currently no reviews for this product. Be the first to review Tocriscreen 2.0 Max and earn rewards!
Have you used Tocriscreen 2.0 Max?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
