TokeOni
Chemical Name: (4S)-2-[(1E,3E)-4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-4,5-dihydro-4-thiazolecarboxylic acid hydrochloride
Purity: ≥90%
Biological Activity
TokeOni is a near-infrared red (NIR)-emission luciferin analog. Peak luminescence at 677 nM. ~40-fold brighter than the luciferin-luciferase system in vitro, and 100-1000 times brighter in vivo. Allows non-invasive visualization of single cells deep inside freely moving animals. Ideal for deep tissue applications. Water soluble (<40 mM), orally bioavailable and brain penetrant.This product is supplied as a hydrochloride salt, the stoichiometry of which is batch dependant. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
Optical Data for TokeOni
| Emission Color | Near-IR |
|---|---|
| λem | 677 nm |
| Application | BLI, BTI, Deep tissue applications |
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.
Kuchimaru et al.
Nat. Commun., 2016;7:11856 -
Unnaturally aglow with a bright inner light.
Nasu et al.
Science, 2018;359:868 -
Single-cell bioluminescence imaging of deep tissue in freely moving animals.
Iwano et al.
Science, 2018;359:935
Product Datasheets
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