Chemical Name: (4S)-2-[(1E,3E)-4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-4,5-dihydro-4-thiazolecarboxylic acid hydrochloride
Biological ActivityNear-infrared red (NIR)-emission luciferin analog. Peak luminescence at 677 nM. ~40-fold brighter than luciferase. 100-1000 times brighter in vivo than conventional systems. Allows non-invasive visualization of single cells deep inside freely moving animals. Orally bioavailable and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.
Kuchimaru et al.
Nat. Commun., 2016;7:11856
Unnaturally aglow with a bright inner light.
Nasu et al.
Single-cell bioluminescence imaging of deep tissue in freely moving animals.
Iwano et al.
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