Topiramate

Tocris Bioscience | Catalog # 3620

GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors
Tocris Bioscience

Key Product Details

Description

GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors

Alternative Names

Topamax
View all Kainate Receptor Antagonists »

Product Description

Topiramate is an anticonvulsant. Antagonizes GluK1 (formerly GluR5) kainate receptors (IC50 = 0.46 μM), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for Topiramate

Molecular Weight

339.36

Formula

C12H21NO8S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

CAS Number

97240-79-4

PubChem ID

5284627

InChI Key

KJADKKWYZYXHBB-XBWDGYHZSA-N

SMILES

CC(O2)(C)O[C@H]1[C@@H]2[C@H](OC(C)(C)O3)[C@@]3(COS(N)(=O)=O)OC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.94 100
Ethanol 33.94 100

Preparing Stock Solutions for Topiramate

The following data is based on the product molecular weight 339.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.47 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for Topiramate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Topiramate

For research use only

⚠ WARNING: This product can expose you to chemicals including Topiramate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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