Anticonvulsant. Antagonizes GluR5 kainate receptors (IC50
= 0.46 μ
M), acts as a positive allosteric modulator of GABAA
receptor-mediated currents, inhibits Nav
= 48.9 μ
M) and inhibits L-type Ca2+
channels. Also inhibits carbonic anhydrase (CA) (Ki
values are 0.1 and 0.2 μ
M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells.
Zona et al.
Topiramate as an inhibitor of carbonic anhydrase isoenzymes.
Dodgson et al.
Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons.
Gryder and Rogawski
Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist.
Kaminiski et al.