Catalog Number: 3620
Alternate Names: Topamax
Chemical Name: 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
Biological Activity
Anticonvulsant. Antagonizes GluR5 kainate receptors (IC50 = 0.46 μM), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells.
    Zona et al.
    Neurosci.Lett., 1997;231:123
  2. Topiramate as an inhibitor of carbonic anhydrase isoenzymes.
    Dodgson et al.
    Epilepsia, 2000;41:S35
  3. Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons.
    Gryder and Rogawski
    J.Neurosci., 2003;23:7069
  4. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist.
    Kaminiski et al.
    Neuropharmacology, 2004;46:1097
Tocris Small Molecules
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Topiramate - d12

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