Inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo
; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.
Soluble to 50 mM in DMSO
Store at RT
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Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone.
Forrest et al.
Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.
Connelly et al.
J.Cardiovascular Pharmacol., 2010;55:459