Chemical Name: N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
Biological ActivityTP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used in vivo. TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo.
To request the negative control for TP 064, please fill out the TP 064N request form on the SGC website..
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Scheer et al.
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Nakayama et al.
Citations for TP 064
The citations listed below are publications that use Tocris products. Selected citations for TP 064 include:
3 Citations: Showing 1 - 3
Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease
Authors: Clemons Et al.
J Cell Physiol 2022;
PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo.
Authors: Zhang Et al.
Biochim.Biophys.Acta Mol.Basis Dis. 2021;1867:166212
CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer.
Authors: Zhong Et al.
Cell Rep 2018;24:3207
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