A selective, competitive GABAA
antagonist with only minimal effects on GABAA
values are 2.1 μ
M (antagonist), 320 μ
M (antagonist) and EC50
~ 500 μ
M (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ
1 receptors over ρ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
GABAC receptor antagonists differentiate between human r1 and r2 receptors expressed in Xenopus oocytes.
Chebib et al.
The involvement of GABA-C receptors in paired pulse depression of inhibitory postsynaptic currents in rat hippocampal CA1 pyramidal neurons.
Xu et al.
Design and in vitro pharmacology of a selective γ-aminobutyric acidc receptor antagonist.
Ragozzino et al.
The first selective antagonist for a GABAc receptor.
Murata et al.
The citations listed below are publications that use Tocris products. Selected citations for TPMPA include:
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