TPMPA

  ( 6 citations )    
Product Datasheet
Catalog Number:1040
Chemical Name:(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
A selective, competitive GABAA-ρ antagonist with only minimal effects on GABAA and GABAB receptors (Kb values are 2.1 μM (antagonist), 320 μM (antagonist) and EC50 ~ 500 μM (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors.
Technical Data
  • M.Wt:
    161.14
  • Formula:
    C6H12NO2P
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    182485-36-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for TPMPA include:

6 Citations: Showing 1 - 6
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  1. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    J Neurosci  2015;9:6
  2. The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.
    Authors: Murphy-Baum and Taylor
    Vis Neurosci  2015;35:13336
  3. Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction.
    Authors: Antonelli Et al.
    Nat Commun  2014;5:5066
  4. Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
    Authors: Olmos-Serrano Et al.
    Br J Pharmacol  2010;30:9929
  5. Retinal input to efferent target amacrine cells in the avian retina.
    Authors: Lindstrom Et al.
    J Neurosci  2010;27:103
  6. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    Front Cell Neurosci  2000;131:1050

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