TPMPA

Tocris Bioscience | Catalog # 1040

Selective GABAA-ρ antagonist
Tocris Bioscience

Key Product Details

Description

Selective GABAA-ρ antagonist
View all GABAA-rho Receptor Antagonists »

Product Description

TPMPA is a selective, competitive GABAA-ρ antagonist with only minimal effects on GABAA and GABAB receptors (Kb values are 2.1 μM (antagonist), 320 μM (antagonist) and EC50 ~ 500 μM (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors.

Product Specifications for TPMPA

Molecular Weight

161.14

Formula

C6H12NO2P

Storage

Store at RT

Purity

≥97% (HPLC)

Chemical Name

(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid

CAS Number

182485-36-5

PubChem ID

5520

InChI Key

MFUKVPOVVKKLRQ-UHFFFAOYSA-N

SMILES

OP(C1=CCNCC1)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for TPMPA

The following data is based on the product molecular weight 161.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.21 mL 31.03 mL 62.06 mL
5 mM 1.24 mL 6.21 mL 12.41 mL
10 mM 0.62 mL 3.10 mL 6.21 mL
50 mM 0.12 mL 0.62 mL 1.24 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 151 publications citing the usage of this product.

Product Documents for TPMPA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TPMPA

For research use only

Related Research Areas

GABA Receptors

Customer Reviews for TPMPA (1)

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  • Used in inhibitor cocktail
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Retinal rod bipolar cells
    Verified Customer | Posted 12/03/2019
    Retinal dissections were performed in HEPES-buffered extracellular solution containing inhibitor cocktail 50 umol/L
    TPMPA 1040

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