Catalog Number: 1558
Alternate Names: ICI 136753
Chemical Name: 4-(Butylamino)-1-ethyl-6-methyl 1H-pyrazolo[3,4b]pyridine-5-ethylcarboxylate hydrochloride
Biological Activity
Subtype-selective GABAA receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Enhances native GABAA receptor function and is anxiolytic following systemic administration in vivo.
Technical Data
  • M.Wt:
    340.85
  • Formula:
    C16H24N4O2.HCl
  • Solubility:
    Soluble to 100 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1135210-68-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate.
    Meiners and Salama
    Eur.J.Pharmacol., 1982;78:315
  2. Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acidA receptors.
    Thompson et al.
    Mol.Pharmacol., 2002;61:861
  3. Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent.
    Patel and Malick
    Eur.J.Pharmacol., 1982;78:323
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tracazolate hydrochloride include:

1 Citations: Showing 1 - 1

  1. Synaptic GABAA receptor clustering without the γ2 subunit.
    Authors: Kerti-Szigeti Et al.
    J Neurosci 2014;34:10219

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