TRAM 1

Tocris Bioscience | Catalog # 8121

Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags
Tocris Bioscience

Key Product Details

Description

Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags
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Product Description

TRAM 1 is a targeted relocalization activating molecule (TRAM) and chemical inducer of proximity for the dTAG protein FKBP12F36V and ecDHFR tags. Can be used to shuttle and redistribute proteins in live cells.

Product Specifications for TRAM 1

Molecular Weight

1009.17

Formula

C54H68N6O13

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(R)-1-(3-(2-((3-(4-((2,4-Diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

InChI Key

SGECTVFBOKCZAI-YZBUDRBASA-N

SMILES

O=C(O[C@H](CCC1=CC(OC)=C(C=C1)OC)C2=CC(OCC(NCCCOC3=C(C=C(C=C3OC)CC4=CN=C(N=C4N)N)OC)=O)=CC=C2)[C@@H]5CCCCN5C([C@@H](CC)C6=CC(OC)=C(C(OC)=C6)OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.92 100

Preparing Stock Solutions for TRAM 1

The following data is based on the product molecular weight 1009.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.99 mL 4.95 mL 9.91 mL
5 mM 0.20 mL 0.99 mL 1.98 mL
10 mM 0.10 mL 0.50 mL 0.99 mL
50 mM 0.02 mL 0.10 mL 0.20 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TRAM 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TRAM 1

For research use only

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