Home / Amyloid beta Peptides / Tramiprosate

Tramiprosate

3619 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3619/50
Tramiprosate | CAS No. 3687-18-1 | Amyloid beta Peptides
1 Image
Description: Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
Alternative Names: Homotaurine

Chemical Name: 3-Amino-1-propanesulfonic acid

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

Technical Data

M.Wt:
139.17
Formula:
C3H9NO3S
Solubility:
Soluble to 100 mM in water
Storage:
Store at +4°C
CAS No:
3687-18-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid.
    Fariello et al.
    Neurology, 1982;32:241
  2. Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis.
    Gervais et al.
    Neurobiol.Aging, 2007;28:537
  3. Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau.
    Santa-Maria et al.
    Mol.Neurodegen., 2007;2:17

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Tramiprosate

There are currently no reviews for this product. Be the first to review Tramiprosate and earn rewards!

Have you used Tramiprosate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.