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Tramiprosate

3619 Datasheet / COA / SDS

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Tramiprosate | CAS No. 3687-18-1 | Amyloid beta Peptides
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Description: Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
Alternative Names: Homotaurine

Chemical Name: 3-Amino-1-propanesulfonic acid

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Biological Activity

Tramiprosate is a sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

Technical Data

M.Wt:
139.17
Formula:
C3H9NO3S
Solubility:
Soluble to 100 mM in water
Storage:
Store at +4°C
CAS No:
3687-18-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid.
    Fariello et al.
    Neurology, 1982;32:241
  2. Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis.
    Gervais et al.
    Neurobiol.Aging, 2007;28:537
  3. Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau.
    Santa-Maria et al.
    Mol.Neurodegen., 2007;2:17

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