Catalog Number: 3619
Alternate Names: Homotaurine
Chemical Name: 3-Amino-1-propanesulfonic acid
Biological Activity
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.
Technical Data
  • M.Wt:
    139.17
  • Formula:
    C3H9NO3S
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at +4°C
  • CAS No:
    3687-18-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid.
    Fariello et al.
    Neurology, 1982;32:241
  2. Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis.
    Gervais et al.
    Neurobiol.Aging, 2007;28:537
  3. Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau.
    Santa-Maria et al.
    Mol.Neurodegen., 2007;2:17

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