Catalog Number: 0538
Chemical Name: trans-4-Hydroxy-2-butenoic acid
Biological Activity
Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself.� May be an endogenous ligand.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Analogues of γ-hydroxybutyric acid. Synthesis and binding studies.
    Bourguignon et al.
    J.Med.Chem., 1988;31:893
  2. Gamma hydroxybutyrate ligands posses antidopaminergic and neuroleptic-like activities.
    Hechler et al.
    J.Pharmacol.Exp.Ther., 1993;264:1406
  3. Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain.
    Vayer et al.
    Biochem.Pharmacol., 1985;34:2401

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