Trequinsin hydrochloride

Catalog # Availability Size / Price Qty
2337/10
Trequinsin hydrochloride | CAS No. 78416-81-6 | Phosphodiesterase Inhibitors
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Description: Highly potent PDE3 inhibitor
Alternative Names: HL-725

Chemical Name: 2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

Purity: ≥97%

Product Details
Citations (1)
Reviews

Biological Activity

Highly potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models. Also activates CatSper channels, increases intracellular Ca2+ and cGMP levels, and decreases potassium channel activity in sperm.

Technical Data

M.Wt:
441.95
Formula:
C24H27N3O3.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Desiccate at RT
CAS No:
78416-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Trequinsin hydrochloride

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