tri-GalNAc-C5-amine

Tocris Bioscience | Catalog # 7781

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry
Tocris Bioscience

Key Product Details

Description

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry
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Product Description

tri-GalNAc-C5-amine is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with an alkylC5 linker and an amine group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Product Specifications for tri-GalNAc-C5-amine

Molecular Weight

1615.75

Formula

C67H118N14O31

Storage

Store at -20°C

Chemical Name

N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide

CAS Number

2098275-86-4

PubChem ID

129115287

InChI Key

WGZBAOGYHCXOAV-WUQQNBSDSA-N

SMILES

CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O)[C@@H]1OCCOCCOCCOCCN(N=N2)C=C2COCC(COCC3=CN(N=N3)CCOCCOCCOCCO[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)(NC(CCCCCN)=O)COCC5=CN(N=N5)CCOCCOCCOCCO[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)CO)O)O)NC(C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 161.57 100

Preparing Stock Solutions for tri-GalNAc-C5-amine

The following data is based on the product molecular weight 1615.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.62 mL 3.09 mL 6.19 mL
5 mM 0.12 mL 0.62 mL 1.24 mL
10 mM 0.06 mL 0.31 mL 0.62 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for tri-GalNAc-C5-amine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for tri-GalNAc-C5-amine

For research use only

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