tri-GalNAc COOH

Tocris Bioscience | Catalog # 7401

Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
Tocris Bioscience

Key Product Details

Description

Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
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Product Description

Tri-GalNAc COOH is a functionalized asialoglycoprotein receptor ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates an asialoglycoprotein receptor (ASGPR) ligand with PEG linker and carboxylic acid group reactive handle ready for conjugation to a target protein ligand. Upon binding to the ASGPR tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. Tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes.

Product Specifications for tri-GalNAc COOH

Molecular Weight

1735.93

Formula

C75H134N10O35

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid

CAS Number

1953146-81-0

InChI Key

SPYOMGAJOYWUJU-JNYSMVCCSA-N

SMILES

O=C(CCOCCOCCOCCOCCOCCC(O)=O)NC(COCCC(NCCCNC(CCCCOC1O[C@@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCOC2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)COCCC(NCCCNC(CCCCOC3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 86.8 50

Preparing Stock Solutions for tri-GalNAc COOH

The following data is based on the product molecular weight 1735.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.15 mL 5.76 mL 11.52 mL
2.5 mM 0.23 mL 1.15 mL 2.30 mL
5 mM 0.12 mL 0.58 mL 1.15 mL
25 mM 0.02 mL 0.12 mL 0.23 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for tri-GalNAc COOH

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for tri-GalNAc COOH

For research use only

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