Trofinetide

Key Product Details

Product Description

Trofinetide is an IGF-1 synthetic analog. It suppresses expression of IL-1β, TNF-α, IFN-γ and E-selectin, and inhibits both acute and delayed neuroinflammation following penetrating ballistic-like brain injury (PBBI) in rats.

Product Specifications for Trofinetide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Trofinetide

The following data is based on the product molecular weight 315.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.17 mL	15.86 mL	31.71 mL
5 mM	0.63 mL	3.17 mL	6.34 mL
10 mM	0.32 mL	1.59 mL	3.17 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wei NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J.Neuroinflammation 2009 PMID: 19656406

Product Documents for Trofinetide