Chemical Name: 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one
Biological ActivitySelective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels.
Häfner et al.
Cell Calcium, 2019;78:26
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