TRPC6-PAM-C20

Tocris Bioscience | Catalog # 6875

Selective positive allosteric modulator (PAM) of TRPC6
Tocris Bioscience

Key Product Details

Description

Selective positive allosteric modulator (PAM) of TRPC6
View all TRPC Channel Activators »

Product Description

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation.

Product Specifications for TRPC6-PAM-C20

Molecular Weight

363.41

Formula

C22H21NO4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one

CAS Number

667427-75-0

PubChem ID

1081484

InChI Key

SNICUMZYPOCXCO-UHFFFAOYSA-N

SMILES

COC1=C(OC)C=C2C(CC(C)(C)N=C2C2=CC3=CC=CC=C3OC2=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.34 100
Ethanol 7.27 20

Preparing Stock Solutions for TRPC6-PAM-C20

The following data is based on the product molecular weight 363.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.52 mL
5 mM 0.55 mL 2.75 mL 5.50 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for TRPC6-PAM-C20

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TRPC6-PAM-C20

For research use only

Related Research Areas

Ion Channels and Regulators

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