TUG 891

Catalog # Availability Size / Price Qty
4601/10
4601/50
Cat.No. 4601 - TUG 891 | C23H21FO3 | CAS No. 1374516-07-0
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Description: Potent and selective FFA4 (GPR120) agonist

Chemical Name: 4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid

Purity: ≥99%

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Biological Activity

Potent FFA4 (GPR120) agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or FFA3). Cell permeable.

Technical Data

M.Wt:
364.41
Formula:
C23H21FO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
1374516-07-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold under license from the University of Southern Denmark.

Background References

  1. Discovery of a potent and selective GPR120 agonist.
    Shimpukade et al.
    J.Med.Chem., 2012;55:4511

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