Catalog Number: 4540
Chemical Name: 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzesulfonamide
Biological Activity
Potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.
Technical Data
  • M.Wt:
    309.32
  • Formula:
    C13H12FN3O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    178606-66-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.
    Lou et al.
    Cancer Res., 2011;71:3364

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