Potent carbonic anhydrase (CA) inhibitor (Ki
values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.
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All Tocris products are intended for laboratory research use only.
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.
Lou et al.
Cancer Res., 2011;71:3364