U0124

  ( 8 citations )    
Product Datasheet
Catalog Number:1868
Chemical Name:Bis[amino(methylthio)methylene]butanedinitrile
Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity
Inactive analog of U0126 (Cat. No. 1144). Does not inhibit MEK at concentrations up to 100 μM. Used as a negative control.

Active Analog also available.

Technical Data
  • M.Wt:
    226.31
  • Formula:
    C8H10N4S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    108923-79-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for U0124 include:

8 Citations: Showing 1 - 8
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  1. MAPK establishes a molecular context that defines effective training patterns for long-term memory formation.
    Authors: Philips Et al.
    Nutr Metab Cardiovasc Dis  2013;33:7565
  2. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
    Authors: Melemedjian Et al.
    Pain  2013;154:1080
  3. Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia.
    Authors: Ye Et al.
    Proc Natl Acad Sci U S A  2012;109:18162
  4. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.
    Authors: Melemedjian Et al.
    Mol Pain  2011;7:70
  5. Influence of chylomicron remnants on human monocyte activation in vitro.
    Authors: Bentley Et al.
    Skelet Muscle  2011;21:871
  6. Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.
    Authors: Kolber Et al.
    J Neurosci  2010;30:8203
  7. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  8. Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway.
    Authors: Chen-Roetling Et al.
    Neuropharmacology  2009;56:922

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