Catalog Number: 1868
Chemical Name: Bis[amino(methylthio)methylene]butanedinitrile
Biological Activity
Inactive analog of U0126 (Cat. No. 1144). Used as a negative control. Does not inhibit MEK at concentrations up to 100 μM.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Identification of a novel inhibitor of mitogen-activated protein kinase kinase.
    Favata et al.
    J.Biol.Chem., 1998;273:18623
  2. Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway.
    J.Physiol., 2000;527:433
  3. Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase A, phosphatidylinositol 3-kinase, and mitogen-activated
    Sekar et al.
    Endocrinology, 2001;142:2921
Tocris Small Molecules
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