U0126

Catalog # Availability Size / Price Qty
1144/5
1144/25
Cat.No. 1144 - U0126 | C18H16N6S2 | CAS No. 109511-58-2
1 Image
Description: Potent, selective inhibitor of MEK1 and 2

Chemical Name: 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene

Product Details
Citations (114)
Supplemental Products
Reviews (1)

Biological Activity

Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Brain penetrant. Helps maintain human pluripotent stem cells in undifferentiated state.

Available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Negative Control also available.

Technical Data

M.Wt:
380.48
Formula:
C18H16N6S2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at +4°C
CAS No:
109511-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Other Product-Specific Information:

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for U0126

The citations listed below are publications that use Tocris products. Selected citations for U0126 include:

114 Citations: Showing 1 - 10

  1. TRIB3 downregulation enhances doxorubicin-induced cytotoxicity in gastric cancer cells.
    Authors: Wu
    Arch Biochem Biophys  2017;622:26
  2. Opposing Actions of Fgf8a on Notch Signaling Distinguish Two Muller Glial Cell Populations that Contribute to Retina Growth and Regeneration.
    Authors: Wan and Goldman
    Cell Rep  2017;19(4):849
  3. Corticotrigeminal Projections from the Insular Cortex to the Trigeminal Caudal Subnucleus Regulate Orofacial Pain after Nerve Injury via Extracellular Signal-Regulated Kinase Activation in Insular Cortex Neurons.
    Authors: Wang Et al.
    Front Cell Neurosci  2016;9:493
  4. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.
    Authors: Yang Et al.
    Nat Commun  2016;7:11385
  5. Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
    Authors: Lee Et al.
    Cardiorenal Med  2016;7:11322
  6. Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection.
    Authors: Zhang Et al.
    Cancer Lett.  2016;371:107
  7. Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.
    Authors: Guo Et al.
    J Neurosci  2016;36:2131
  8. AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons.
    Authors: Tuvikene Et al.
    J Neurosci  2016;36:1290
  9. Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK.
    Authors: Dang Et al.
    Korean J Physiol Pharmacol  2016;13:12
  10. Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment.
    Authors: Liu Et al.
    Mol Cancer  2015;5:79
  11. A temporal shift in the circuits mediating retrieval of fear memory.
    Authors: Do-Monte Et al.
    J Neuroinflammation  2015;519:460
  12. Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma.
    Authors: Koerber Et al.
    Int J Cancer  2015;4:21
  13. MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy.
    Authors: Li Et al.
    Brain Behav.Immun.  2015;49:255
  14. Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST.
    Authors: Meyer Et al.
    Mol Cell Biol  2015;35:2991
  15. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity.
    Authors: Briz Et al.
    Exp Hematol Oncol  2015;35:2269
  16. IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer.
    Authors: Zhao Et al.
    Nature  2015;34:1596
  17. Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis.
    Authors: Saliba Et al.
    J Am Soc Nephrol  2015;26:1855
  18. P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance.
    Authors: Tang Et al.
    J Immunol  2015;195:1191
  19. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
    Authors: Lourenco Et al.
    J Immunol  2015;194:3463
  20. Receptor protein tyrosine phosphatase β/ζ is a functional binding partner for vascular endothelial growth factor.
    Authors: Koutsioumpa Et al.
    J Neurosci  2015;14:19
  21. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
    Authors: Choi Et al.
    J Neurosci  2015;136:E219
  22. Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model.
    Authors: Sovadinova Et al.
    Oncogene  2015;10:e0124454
  23. Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.
    Authors: Grell Et al.
    PLoS One  2014;9:e113624
  24. hesperidin induces paraptosis like cell death in hepatoblastoma, HepG2 Cells: involvement of ERK1/2 MAPK [corrected].
    Authors: Yumnam Et al.
    PLoS One  2014;9:e101321
  25. Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration.
    Authors: Wan Et al.
    Neuroscience  2014;9:285
  26. Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex.
    Authors: Christianson Et al.
    Front Behav Neurosci  2014;8:348
  27. Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching.
    Authors: Guemez-Gamboa Et al.
    Neuron  2014;82:1004
  28. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.
    Authors: Alpár Et al.
    Cell Rep  2014;5:4421
  29. Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo.
    Authors: Wan Et al.
    FASEB J  2014;28:3456
  30. Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells.
    Authors: Emery Et al.
    J Biol Chem  2014;289:10126
  31. ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer.
    Authors: Heckler Et al.
    FEBS J  2014;281:2431
  32. δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
    Authors: Liang Et al.
    J Neuroinflammation  2014;171:5417
  33. TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Babu Et al.
    BMC Cancer  2014;14:113
  34. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
    Authors: Schubert Et al.
    Acta Neuropathol  2014;128:835
  35. MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.
    Authors: Grzmil Et al.
    J Clin Invest  2014;124:742
  36. Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase activation in mice.
    Authors: Nemoto Et al.
    Mol Pain  2013;9:38
  37. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.
    Authors: Voon Et al.
    PLoS One  2013;8:e70427
  38. Polycyclic aromatic hydrocarbon-induced signaling events relevant to inflammation and tumorigenesis in lung cells are dependent on molecular structure.
    Authors: Osgood Et al.
    PLoS One  2013;8:e65150
  39. The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer.
    Authors: Lucchetti Et al.
    PLoS One  2013;8:e55355
  40. Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells.
    Authors: Li Et al.
    Invest Ophthalmol Vis Sci  2013;54:2872
  41. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy.
    Authors: Berdichevsky Et al.
    J Neurosci  2013;33:9056
  42. MAPK establishes a molecular context that defines effective training patterns for long-term memory formation.
    Authors: Philips Et al.
    J Neurosci  2013;33:7565
  43. Acute mitochondrial inhibition by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitors regulates proliferation.
    Authors: Ripple Et al.
    J Biol Chem  2013;288:2933
  44. Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
    Authors: Korb Et al.
    Nat Neurosci  2013;16:874
  45. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
    Authors: Melemedjian Et al.
    Pain  2013;154:1080
  46. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
    Authors: Morse Et al.
    BMC Pharmacol Toxicol  2013;14:17
  47. An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection.
    Authors: Jensen Et al.
    J Neurosci  2013;13:67
  48. Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes.
    Authors: Meyer Et al.
    J Pharmacol Exp Ther  2013;11:6
  49. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;
  50. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
    Authors: Gangoiti Et al.
    Biochimie  2012;94:597
  51. Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6).
    Authors: Yan Et al.
    Mol Pain  2012;8:6
  52. Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway.
    Authors: Zhang Et al.
    J Virol  2012;86:1544
  53. Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways.
    Authors: Li Et al.
    J Virol  2012;86:12531
  54. Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways.
    Authors: Lee Et al.
    PLoS One  2012;7:e50624
  55. Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT.
    Authors: Chen Et al.
    Int J Mol Med  2012;30:1021
  56. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
    Authors: Breshears Et al.
    J Biol Chem  2012;287:32578
  57. Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.
    Authors: Arora Et al.
    Cell Commun Signal  2012;10:19
  58. Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis.
    Authors: Schulz Et al.
    Proc Natl Acad Sci U S A  2012;109:E2665
  59. Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia.
    Authors: Ye Et al.
    Proc Natl Acad Sci U S A  2012;109:18162
  60. Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion.
    Authors: Hodges Et al.
    Exp Eye Res  2012;103:99
  61. Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF.
    Authors: Dohgu Et al.
    Br J Pharmacol  2011;8:167
  62. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide.
    Authors: Kovac Et al.
    J Neurosci  2011;8:139
  63. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.
    Authors: Melemedjian Et al.
    Mol Pain  2011;7:70
  64. A screen for regulators of survival of motor neuron protein levels.
    Authors: Makhortova Et al.
    Nat Chem Biol  2011;7:544
  65. Interleukin-2 Functions in Anaplastic Large Cell Lymphoma Cells through Augmentation of Extracellular Signal-Regulated Kinases 1/2 Activation.
    Authors: Ito Et al.
    Int J Biomed Sci  2011;7:181
  66. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  67. CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
    Authors: Roselli Et al.
    PLoS One  2011;6:e23097
  68. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    J Neurosci  2011;31:725
  69. JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.
    Authors: Hsu Et al.
    Cell Commun Signal  2011;18:61
  70. Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathways.
    Authors: Mou Et al.
    Respir Res  2011;176:72
  71. Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells.
    Authors: Kim Et al.
    Mol Cancer  2011;15:211
  72. ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.
    Authors: Sbroggiò Et al.
    J Cell Sci  2011;124:3515
  73. Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.
    Authors: Rubert Et al.
    BMC Cancer  2011;11:24
  74. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  75. Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors.
    Authors: Braun Et al.
    J Mol Cell Cardiol  2010;49:362
  76. Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish.
    Authors: Ishida Et al.
    Dev Biol  2010;340:468
  77. Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.
    Authors: Kolber Et al.
    Nat Commun  2010;30:8203
  78. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  79. IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex.
    Authors: Melemedjian Et al.
    J Neurosci  2010;30:15113
  80. Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.
    Authors: Chen Et al.
    J Neurosci  2010;30:10360
  81. Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression.
    Authors: Beshir Et al.
    Cancer Lett  2010;299:137
  82. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  83. Synergistic growth inhibition of anaplastic large cell lymphoma cells by combining cellular ALK gene silencing and a low dose of the kinase inhibitor U0126.
    Authors: Ito Et al.
    Cancer Gene Ther  2010;17:633
  84. Assessment of the role of MAP kinase in mediating activity-dependent transcriptional activation of the immediate early gene Arc/Arg3.1 in the dentate gyrus in vivo.
    Authors: Chotiner Et al.
    Learn Mem  2010;17:117
  85. The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells.
    Authors: Le Et al.
    J Invest Dermatol  2010;130:2240
  86. Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype.
    Authors: Pera Et al.
    J Neurosci  2010;11:48
  87. ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity.
    Authors: He and Aizenman
    J Neurochem  2010;114:452
  88. 4-hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of IkappaB kinase: potential role of reactive oxygen species.
    Authors: Park Et al.
    Cancer Res  2009;69:2416
  89. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One  2009;4:e6011
  90. BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.
    Authors: Zhong Et al.
    J Neurosci  2009;29:9977
  91. The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons.
    Authors: Pintchovski Et al.
    J Neurosci  2009;29:1525
  92. Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.
    Authors: Riedl Et al.
    PLoS One  2009;29:13377
  93. PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
    Authors: Doulatov Et al.
    Genes Dev  2009;23:2076
  94. Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways.
    Authors: Tsuda Et al.
    J Cell Mol Med  2009;13:3251
  95. Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation.
    Authors: Magliaro and Saldanha
    Brain Res  2009;1283:14
  96. Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems.
    Authors: Upham Et al.
    Environ Health Perspect  2009;117:545
  97. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.
    Authors: Roscioni Et al.
    Respir Res  2009;10:88
  98. Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus.
    Authors: Coba Et al.
    J Biol Chem  2008;283:34101
  99. Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway.
    Authors: Dohgu and Banks
    Exp Neurol  2008;210:740
  100. The novel adipocytokine visfatin exerts direct cardioprotective effects.
    Authors: Lim Et al.
    J Cell Mol Med  2008;12:1395
  101. Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis.
    Authors: Liu Et al.
    Am J Physiol Cell Physiol  2007;293:C682
  102. Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites.
    Authors: Huang Et al.
    J Neurosci  2007;27:9054
  103. Catecholaminergic control of mitogen-activated protein kinase signaling in paraventricular neuroendocrine neurons in vivo and in vitro: a proposed role during glycemic challenges.
    Authors: Khan Et al.
    Nat Commun  2007;27:7344
  104. Insulin induces airway smooth muscle contraction.
    Authors: Schaafsma Et al.
    J Biomed Sci  2007;150:136
  105. Role of glycogen synthase kinase 3 β (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells.
    Authors: Alao Et al.
    J Neurosci  2006;5:40
  106. Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors.
    Authors: O'Riordan Et al.
    Cell Host Microbe  2006;26:4870
  107. Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
    Authors: Kauppinen Et al.
    Proc Natl Acad Sci U S A  2006;103:7136
  108. Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia.
    Authors: Bellik Et al.
    Br J Pharmacol  2005;146:568
  109. Morphological effects of estrogen on cholinergic neurons in vitro involves activation of extracellular signal-regulated kinases.
    Authors: Dominguez Et al.
    J Neurosci  2004;24:982
  110. Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
    Authors: Gallagher Et al.
    J Neuroinflammation  2004;24:4859
  111. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well a
    Authors: Wang Et al.
    J Neurosci  2004;24:3370
  112. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
    Authors: Pierre Et al.
    EMBO J  2004;23:3031
  113. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation.
    Authors: Atherton Et al.
    Am J Physiol Lung Cell Mol Physiol  2003;285:L730
  114. Role of the extracellular signal-regulated kinase (Erk) signal transduction cascade in alpha(2) adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein.
    Authors: Roberts
    Br J Pharmacol  2001;133:859

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Tocris Small Molecules

Reviews for U0126

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used U0126?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Fast delivery and great quality
By Anonymous on 07/17/2017
Species: Mouse

To block the gpcr signaling and determine the pathway of an orphan receptor


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.