Potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50
= 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50
values are 78.6, 142 and 165 μ
M, respectively). Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?
Van Goethem et al.
Dipeptidyl peptidase 8/9-like activity in human leukocytes.
Maes et al.