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UCB 9386

Catalog #: 8914 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8914/10

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UCB 9386 | NUAK Inhibitors
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Description: Potent and selective CNS penetrant NUAK1 inhibitor

Chemical Name: (R)-7-(Imidazo[1,2-b]pyridazin-3-yl)-3-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)-1-(1-phenylethyl)pyrido[3,4-b]pyrazin-2(1H)-one

Purity: ≥98%

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Biological Activity

UCB 9386 is a potent and selective central nervous system penetrant NUAK1 (NUAK family SnF1-like kinase-1) inhibitor (pIC50= 10.1). Kinome selectivity measured in the diversity panel shows that only Jak2 and Nuak2 are inhibited more than 50% at 10 nM. In vivo, UCB 9386 exhibits high brain penetrance.

Technical Data

M.Wt:
478.56
Formula:
C27H26N8O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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