UCH-L1/PGP9.5 Antibody - BSA Free

Novus Biologicals | Catalog # NBP2-24781

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Canine, Primate

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all UCH-L1/PGP9.5 Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acids 50-100 of human UchL1 was used as the immunogen for this antibody.

Marker

pan-Neuronal Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UCH-L1/PGP9.5 Antibody - BSA Free

Western Blot: UCH-L1/PGP9.5 Antibody [NBP2-24781]

Western Blot: UCH-L1/PGP9.5 Antibody [NBP2-24781]

Western Blot: PGP9.5 / UCHL-1 Antibody [NBP2-24781] - Western blot analysis of PGP9.5 / UCHL-1 in human brain lysate in the 1) absence and 2) presence of immunizing peptide using PGP9.5 / UCHL-1 antibody at 0.2 ug/ml.
Immunohistochemistry-Paraffin: UCH-L1/PGP9.5 Antibody [NBP2-24781]

Immunohistochemistry-Paraffin: UCH-L1/PGP9.5 Antibody [NBP2-24781]

Immunohistochemistry-Paraffin: PGP9.5 / UCHL-1 Antibody [NBP2-24781] - IHC analysis of human brain, cortex, using PGP9.5 / UCHL-1 antibody at 10 ug/ml.

Applications for UCH-L1/PGP9.5 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

0.1-1 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS and 0.2% Gelatin

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: UCH-L1/PGP9.5

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a soluble cytoplasmic protein found in neurons and in cells of the diffuse neuroendocrine system, and their respective tumors. Therefore, UCH-L1 has been widely used as a peripheral nerve fiber marker. UCHL-1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme involved in the processing of both ubiquitin precursors and ubiquitinated proteins.

UCH L1 is down-regulated in brains from Parkinson disease and Alzheimer disease patients, and certian site specific mutations in the UCHL1 gene can either increase or decrese the risk of Parkinson's and/or Alzheimer's neurodegenerative diseases.

Human UCHL 1 and the closely related UCHL3 protein have one of the most complicated knot structures ever discovered, with five knot crossings. This knot structure is expected to help the protein resist degradation in the proteasome.

Long Name

Ubiquitin C-terminal Hydrolase L1

Alternate Names

PARK5, PGP9.5, UCHL1

Gene Symbol

UCHL1

UniProt

P09936 (Human)

Additional UCH-L1/PGP9.5 Products

Product Documents for UCH-L1/PGP9.5 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for UCH-L1/PGP9.5 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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