UCLA GP130 2
Chemical Name: N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
Biological Activitygp130 agonist. Protects against NMDA-induced toxicity in primary hippocampal neurons in vitro. Increases STAT3 phosphorylation in SH-SY5Y cells. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity.
Alam et al.
ACS Chem.Neurosci., 2018;9:462
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