Catalog Number: 1552
Alternate Names: [Nphe1,Arg14,Lys15]Nociceptin-NH2
Biological Activity
Potent, selective and competitive silent antagonist for the NOP opioid receptor. Binds to NOP with high affinity (pKi = 10.24) and displays > 3000-fold selectivity over δ, μ and κ opioid receptors. Antinociceptive and opposes the action of nociceptin in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Gly-1 = N-(Bn)Gly, Gln-17 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. [Nphe1,Arg14,Lys15]Nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.
    Calo et al.
    Br.J.Pharmacol., 2002;136:303
  2. Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.
    Gavioli et al.
    Eur.J.Neurosci., 2003;17:1987
  3. UFP-101, a high affinity antagonist for the nociceptin/orphanin FQ receptor: radioligand and GTPγ35 binding studies.
    McDonald et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 2003;367:183
  4. Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex.
    Marti et al.
    Br.J.Pharmacol., 2003;138:91

The citations listed below are publications that use Tocris products. Selected citations for UFP-101 include:

2 Citations: Showing 1 - 2
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  1. Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons.
    Authors: Mahmoud Et al.
    Mol Pharmacol 2010;77:804
  2. Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
    Authors: Kuzmin Et al.
    Br J Pharmacol 2004;141:132

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