UH15-38

Tocris Bioscience | Catalog # 8104

Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis
Tocris Bioscience

Key Product Details

Description

Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis
View all RIP Kinase Inhibitors »

Product Description

UH15-38 is a potent and selective receptor interacting protein kinase 3 (RIPK3) inhibitor (IC50 = 20 nM). UH15-38 potently and selectively blocks influenza A-induced necroptosis in alveolar epithelial cells in vivo (IC50 = 39.5 nM), and prevents damage from lung inflammation without compromising antiviral adaptive immune responses or impeding viral clearance. Blocks TNFα-induced necroptosis in primary murine embryonic fibroblasts (IC50 = 98 nM) and mouse cell lines in vitro.

Scientific Data Images for UH15-38

Published vs Bio-Techne batch comparison for UH15-38

Published vs Bio-Techne batch comparison for UH15-38.

Inhibition of necroptosis by UH15-38 in human FADD-deficient Jurkat cells. Cells were treated with 10 ng/ml of human TNF alpha for 24 hr in the presence of the dose range of the inhibitors. Cell viability was determined using CellTiter-Glo assay (Promega). IC50 for the published molecule was 238.2 nM and 160.2 nM for the Bio-Techne batch. Data kindly provided by A. Degterev’s laboratory, University of Tufts.

Licensing Information

Sold under license from Tufts University

Product Specifications for UH15-38

Molecular Weight

514.45

Formula

C26H27N5O2.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-(3-Hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one dihydrochloride

InChI Key

HIVPDYQXZCXJQM-UHFFFAOYSA-N

SMILES

O=C1C(C2=CC=CC(O)=C2)=CC3=C(N1C)C=C(NC4=CC=CC(N5CCN(CC5)C)=C4)N=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 51.44 100
DMSO 51.44 100

Preparing Stock Solutions for UH15-38

The following data is based on the product molecular weight 514.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.72 mL 19.44 mL
5 mM 0.39 mL 1.94 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for UH15-38

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for UH15-38

For research use only

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