UK 370106

Key Product Details

Product Description

UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC₅₀ values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC₅₀ = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.

Product Specifications for UK 370106

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UK 370106

The following data is based on the product molecular weight 572.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.75 mL	8.73 mL	17.46 mL
5 mM	0.35 mL	1.75 mL	3.49 mL
10 mM	0.17 mL	0.87 mL	1.75 mL
50 mM	0.03 mL	0.17 mL	0.35 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Whitlock A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts.
• Matthews Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics
• Fray A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 2003 PMID: 12877590

Product Documents for UK 370106