Catalog Number: 2900
Chemical Name: (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid
Biological Activity
Highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.
Technical Data
  • M.Wt:
    572.73
  • Formula:
    C35H44N2O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    230961-21-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers.
    Fray et al.
    J.Med.Chem., 2003;46:3514
  2. A novel series of highly selective inhibitors of MMP-3.
    Whitlock et al.
    Bioorg.Med.Chem.Letts., 2007;17:6750
Citations:

The citations listed below are publications that use Tocris products. Selected citations for UK 370106 include:

1 Citations: Showing 1 - 1

  1. Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo.
    Authors: Agren Et al.
    J Biol Chem 2015;94:44531

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