UK 370106

  ( 1 citations )    
Product Datasheet
Catalog Number:2900
Chemical Name:(βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid
Product Details
Citations (1)
Reviews
Biological Activity
Highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.
Technical Data
  • M.Wt:
    572.73
  • Formula:
    C35H44N2O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >95
  • Storage:
    Store at -20°C
  • CAS No:
    230961-21-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for UK 370106 include:

1 Citations: Showing 1 - 1

  1. Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo.
    Authors: Agren Et al.
    J Biol Chem  2015;94:44531

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