Highly selective MMP-3 and MMP-12 inhibitor (IC50
values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μ
M at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50
= 320 nM) and has little effect on keratinocyte migration in vitro
. Substantially inhibits MMP-3 in an ex vivo
model of chronic dermal ulcers.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers.
Fray et al.
A novel series of highly selective inhibitors of MMP-3.
Whitlock et al.
The citations listed below are publications that use Tocris products. Selected citations for UK 370106 include:
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