UK 383367

Key Product Details

Product Description

UK 383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC₅₀ = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC₅₀ values are >10,000 nM for listed MMPs).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for UK 383367

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UK 383367

The following data is based on the product molecular weight 324.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.41 mL	30.83 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Fish Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J.Med.Chem. 2007 PMID: 17591762
• Bailey Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 2008 PMID: 18945617
• Allan Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 2006 PMID: 16854779

Product Documents for UK 383367