Chemical Name: 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
Biological ActivityPotent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.
Allan et al.
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.
Fish et al.
Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents.
Bailey et al.
Citation for UK 383367
The citations listed below are publications that use Tocris products. Selected citations for UK 383367 include:
1 Citation: Showing 1 - 1
Vascular smooth muscle cells direct extracellular dysregulation in aortic stiffening of hypertensive rats.
Authors: Hays Et al.
Aging Cell 2018;17:e12748
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