Catalog Number: 4186
Chemical Name: 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
Biological Activity
Inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications.
    Wiemer et al.
    Biochem.J., 1995;312:479
  2. Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae.
    Hildyard et al.
    Biochem.J., 2003;374:607
  3. A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts.
    Hinoi et al.
    Mol.Pharmacol., 2006;70:925

The citations listed below are publications that use Tocris products. Selected citations for UK 5099 include:

1 Citations: Showing 1 - 1

  1. SCFA transport in rat duodenum.
    Authors: Kaji Et al.
    Nat Chem Biol 2015;308:G188

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